GGTI 298

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GGTI 298 是一种香叶基香叶基转移酶 I 抑制剂，能够将人类肿瘤细胞阻滞在细胞周期的 G1 期并诱导细胞凋亡。

GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.

RhoA inhibitor (GGTI298 Trifluoroacetate) significantly reduces cAMP agonist-stimulated apical K+ conductance. Knockdown of DR4 abolishes NF-κB activation, leading to sensitization of DR5-dependent apoptosis induced by the combination of GGTI298 Trifluoroacetate and TRAIL. GGTI298 Trifluoroacetate/TRAIL activates NF-κB and inhibits Akt. Knockdown of DR5, prevents GGTI298/TRAIL-induced IκBα and p-Akt reduction, suggesting that DR5 mediates reduction of IκBα and p-Akt induced by GGTI298/TRAIL. In contrast, DR4 knockdown further facilitates GGTI298/TRAIL-induced p-Akt reduction.

The vivo mouse ileal loop experiments show fluid accumulation is reduced in a dose-dependent manner by TRAM-34, GGTI298 Trifluoroacetate, or H1152 when inject together with cholera toxin into the loop.

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Others

Other Targets

GGTase I

Others-Field

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1217457-86-7

593.66

C27H33N3O3S·C2HF3O2

>98% (HPLC)

DMSO : 150 mg/mL 252.67 mM;

OC(=O)C(F)(F)F.SC[C@@H](CNc1ccc(c(c1)c1cccc2c1cccc2)C(=O)N[C@H](C(=O)OC)CC(C)C)N

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(-20℃)

With Ice Pack

≥ 2 years